Ep. 288: “Cerebellar Organoids” Featuring Dr. Giorgia Quadrato
Dr. Giorgia Quadrato is Assistant Professor of Stem Cell and Regenerative Medicine at the University of Southern California. Her research focuses on brain developmental and neural organoids. She talks about protocols for generating cerebellar organoids, including those with functional Purkinje cells. She also discusses a transcriptomic atlas of neural organoids and the stem cell research landscape in California.
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1:22:28
Ep. 287: “Blood Development” Featuring Drs. Andrew Elefanty and Elizabeth Ng
Drs. Andrew Elefanty and Elizabeth Ng are Senior Principal Investigator and Principal Investigator, respectively, at the Murdoch Children's Research Institute. In the Blood Development group, they aim to develop innovative cellular therapies for blood and cartilage-related diseases. They talk about their recent study deriving and transplanting HSCs, their work on reporter lines, and their collaborative lab setup.
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1:29:09
Ep. 286: “Neural Lineage Identity” Featuring Dr. Marius Wernig
Dr. Marius Wernig is a Professor of Pathology and a Co-Director of the Institute for Stem Cell Biology and Regenerative Medicine at Stanford University, where his research interests include direct reprogramming and neurological disease modeling. He talks about his early work reprogramming neuronal cells from fibroblasts, adopting iPSCs, and growing his lab. He also discusses his recent research on cell therapy for brain and skin diseases, as well as his musical talents outside of the lab.
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1:24:07
Ep. 285: “Funding the Future” Featuring Dr. Jonathan Thomas
Guest:
Dr. Jonathan Thomas "JT" is the President and CEO of the California Institute for Regenerative Medicine (CIRM), an organization that provides funding for stem cell research with the purpose of accelerating treatments for patients in need. He talks about working to ensure diversity in clinical trials and developing treatments that are affordable and accessible to patients. He also discusses the progress during the twenty years since CIRM's inception, training the next generation of scientists, and balancing support for basic and clinical research. (41:03)
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Cell Quality Attributes of Human Pluripotent Stem Cells
The Stem Cell Science Round Up
Regulating Naive Pluripotency – Scientists used a targeted rapid protein degradation system to show that GABPA is a master pluripotency regulator. (1:36)
Skin Wound Healing – A spatiotemporal atlas of human skin wound tissues identifies FOSL1 as a critical driver of re-epithelialization. (11:50)
Bone Marrow Stem Cell Niches – The bone marrow niche orchestrates hierarchy in stem cells and immune tolerance. (20:49)
Synthetic Organizer Cells – Synthetic organizer cells self-assemble around stem cells and produce morphogens. (30:50)
Image courtesy of Dr. Jonathan Thomas
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1:31:54
Ep. 284: “Organ Chip Engineering” Featuring Dr. Milica Radisic
Dr. Milica Radisic is a Professor and Canada Research Chair at the University of Toronto. Her lab uses organ-on-a-chip engineering to mimic physiology of the heart, kidney, and vasculature for the purpose of modeling human disease and discovering more effective drugs. In this episode, she talks about the challenges of studying the heart and strategies to mature cardiomyocytes. She also discusses using macrophages to vascularize heart-on-a-chip platforms and enhance cardiac tissue function, sustainability considerations for microfluidic chips, and how these disease models can reduce the use of lab animals. Finally, she talks about starting a company to commercialize her lab's cardiac chip platform, the landscape for women entrepreneurs, and advice from her mentor, Dr. Bob Langer.
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