Daily Value

• The Melatonin Mystery: Are Guidelines Wrong?

  In this episode of Daily Value, we look at newer research on melatonin that challenges conventional wisdom. A recent meta‐analysis questions current clinical guidelines on melatonin use for sleep, suggesting there may be a dual (Dose X Time effect) secret to optimizing its effects. We’ll break down the scientific clues behind optimal dosing, timing, and formulation, leaving you to wonder if you've been taking melatonin all wrong.Discussion Points:The clinical recommendations for melatonin may be “off”.What a recent meta-analysis (PMID: 38888087) suggests as better dosing and timing of melatonin.Formulation differences between fast-acting and extended-release melatonin.Practical tips for tailoring melatonin to boost your sleep quality.https://pubmed.ncbi.nlm.nih.gov/38888087/ Support the show

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  9:06
• B Vitamins & Neuropsychiatric Disorders—A Causal Relationship

  In this episode of Daily Value, we look at the latest research on B vitamins and their in neuropsychiatric disorders. A newly published meta-analysis suggests a causal relationship between B vitamin deficiencies and neuropsychiatric disorders. We will break down the scientific findings on B6, B12, and folate, shedding light on their roles in conditions like Parkinson’s disease.Discussion Points:How recent genetic studies support a causal link between B vitamin deficiencies and mental health conditions.The role of B vitamins in reducing neurotoxicity and slowing brain atrophy.How vitamin B12 may protect against dopamine neuron loss and disease progression.Evidence linking low B6 levels to neurotransmitter imbalances and schizophrenia risk.The impact of folate on one-carbon metabolism and its protective role in neurodegeneration.https://www.sciencedirect.com/science/article/abs/pii/S0149763425000685#:~:text=In a meta-analysis of,beneficial for certain specific diseases.https://pubmed.ncbi.nlm.nih.gov/26757190/https://pubmed.ncbi.nlm.nih.gov/32257364/https://pubmed.ncbi.nlm.nih.gov/30858560/https://pubmed.ncbi.nlm.nih.gov/32424116/https://pubmed.ncbi.nlm.nih.gov/33941768/Support the show

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  9:59
• The Forgotten Vitamin for Brain Health

   In today’s episode of Daily Value, we explore the possibly underappreciated role of vitamin K in brain health and neuroprotection. Recent research (doi: 10.3389/fnut.2024.1396707) reveals a connection between dietary vitamin K intake and reduced levels of neurofilament light chain, a potential biomarker for neurodegeneration, particularly in middle-aged and older adults. We’ll discuss how vitamin K supports neuronal function, what specific forms of vitamin K are most important, and how this nutrient might help slow cognitive decline as we age.Episode Talking Points:*The role of neurofilament light chain as a biomarker for brain health and its association with neurodegeneration.*Findings from a recent study (doi: 10.3389/fnut.2024.1396707) showing how higher vitamin K intake (and a specific amount) is linked to lower neurofilament light chain levels.*The potential of vitamin K, and possibly MK-4, to protect neurons through mechanisms like sphingolipid metabolism and anti-inflammatory effects.https://www.frontiersin.org/journals/nutrition/articles/10.3389/fnut.2024.1396707/full Support the show

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  10:57
• Beyond the Gym: Creatine’s Role in Women’s Health

  In this episode of Daily Value, we look at the emerging research on creatine supplementation in women’s health—beyond its well-established role in exercise performance. With evidence mounting on creatine’s impact across menstruation, pregnancy, postpartum recovery, and menopause, we discuss how it supports cognition, mood stabilization, and bone health throughout a woman’s lifespan.Discussion Points:Creatine & Hormonal Fluctuations: How estrogen and progesterone influence creatine uptake and metabolism.Cognitive & Mood Benefits: The role of creatine in reducing brain fog, fatigue, and potentially postpartum depression.Pregnancy & Fetal Development: How maternal creatine status may impact fetal neurodevelopment and birth outcomes.Menopause & Bone Health: The effect of creatine on osteoblast activity, muscle preservation, and sarcopenia prevention.Dosing Guidelines for Womenhttps://pmc.ncbi.nlm.nih.gov/articles/PMC7998865/https://pubmed.ncbi.nlm.nih.gov/39796530/Support the show

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  9:40
• B12 Deficiency: Uncovering the Silent Threat to Neurological and Vascular Health

  In today’s episode of Daily Value, we take a closer look at a commonly overlooked but essential nutrient: vitamin B12. Known as cobalamin, vitamin B12 deficiency can lead to severe neurological, hematological, and cognitive issues if left unchecked. We’ll cover the causes behind this growing issue, from dietary intake to malabsorption.Episode Talking Points:The role of B12 in nervous system function and red blood cell production.Causes of B12 deficiency, including dietary factors, autoimmune conditions, and genetic predispositions.Treatment approaches, including supplementation methods and the importance of early diagnosis.https://pubmed.ncbi.nlm.nih.gov/38987879/ https://www.nature.com/articles/nrdp201740Support the show

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  14:59

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